Among the explanations offered for tau’s detrimental effects on neurons in Alzheimer disease is that elevations in tau levels, and/or changes in its cellular distribution, disrupt microtubule function ...

Neurons, specialized cells that transmit information across the nervous system, communicate with each other via projections ...

Mutations in copper/zinc superoxide dismutase 1 (SOD1), primary causes of human amyotrophic lateral sclerosis (ALS), provoke motor neuron death through an unidentified toxic property. The known ...

A physical dimension of a cell is seldom its Achilles' heel. Yet for the neurons that are affected in most kinds of peripheral neuropathy, it is the length of their axons that best accounts for their ...

Neurons, with their large cell bodies and extensive processes, depend on a delicately balanced intracellular transport machinery to keep in touch with their own outer reaches. Inequalities between ...

(Medical Xpress)—Neurons have developed elaborate mechanisms for transporting critical components, like transmitter-laden vesicles, down their axons to the synaptic terminations. An axon in a blue ...

Seeking students to contribute to research exploring motor-disease protein complexes and their role in intracellular transport, as they relate to disease initiation and the aging process, and the ...

Local mRNA translation is a post-transcriptional gene regulatory mechanism that enables autonomous control of local proteomes in subcellular compartments. This mechanism operates in neuronal dendrites ...

RNA granules, sites for the storage, transport, and regulation of RNA molecules within cells, are transported along axons and then translated locally, far from the cell body. Recent studies suggest ...

Alzheimer's dementia is caused by accumulation of amyloid-β protein in neurons, formed from proteolytisis of amyloid precursor protein (APP), but the normal role of APP in the brain remains unclear.

Chong Kun Dang said on the 3rd that it presented the preclinical (animal and cell experiment stage) research results of its degenerative neurological disease drug candidate "CKD-513" in a poster at ...