Neurons, specialized cells that transmit information across the nervous system, communicate with each other via projections ...

RNA granules, sites for the storage, transport, and regulation of RNA molecules within cells, are transported along axons and then translated locally, far from the cell body. Recent studies suggest ...

The regulation of brain iron homeostasis, previously thought to be cell autonomous and modulated by local factors in the interstitial fluid, is reported by Wang et al. to be strongly influenced by ...

Axons extend for tremendously long distances from the neuronal soma and make use of localized mRNA translation to rapidly respond to different extracellular stimuli and physiological states. The ...

Seeking students to contribute to research exploring motor-disease protein complexes and their role in intracellular transport, as they relate to disease initiation and the aging process, and the ...

A study in yesterday's Neuron suggests that Alzheimer's disease might be linked to a disruption of protein transport machinery in neurons. Shermali Gunawardena and Lawrence Goldstein at UC San Diego ...

A protein linked to accumulation of harmful brain plaque in Alzheimer’s patients has been shown in fruit flies and mice to be an important part of a molecular transportation system that moves signals ...

Alzheimer's dementia is caused by accumulation of amyloid-β protein in neurons, formed from proteolytisis of amyloid precursor protein (APP), but the normal role of APP in the brain remains unclear.

Huntington's disease is a genetic neurodegenerative disorder caused by mutations in the protein huntingtin and characterized by involuntary dance-like movements, severe behavioural changes and ...