KATMAP: A new way to understand and predict gene splicing

Although heart cells and skin cells contain identical instructions for creating proteins encoded in their DNA, they're able ...
EMBO Press

Closing the loop on EGFR therapy: decoding cetuximab response through circ-EGFR

Over the past decade, several tumor-based predictors of cetuximab efficacy have been identified, yet most function as ...
Fred Hutch

Circling back to RNA sequencing data to map recursive splice sites

The human genome is just over 6 feet 8 inches long, which is 2 inches taller than the average NBA basketball player and in total, a lot of nucleotides! But what if the amount of sequence diversity ...
EurekAlert!

Multiple Splicing Forms of the TP63 Gene (IMAGE)

The TP63 gene, an important member of the TP53 family, contains two independent promoters that drive the transcription of TAp63 and ΔNp63, respectively. Through alternative splicing, TAp63 and ΔNp63 ...