The main component of Alzheimer’s plaques—fibrillar aggregates of amyloid-β(1-42) (Aβ42)—pose a sticky problem for structural biologists. In the past few years, groups have used various biophysical ...

This is a preview. Log in through your library . Abstract Amyloid-β (Aβ) fibrils exhibit self-propagating, molecular-level polymorphisms that may contribute to variations in clinical and pathological ...

Amyloid fibrils appear in many neurodegenerative diseases, and scientists are eager to understand how they form and spread. But amyloids—clumped aggregations of misfolded proteins—can be difficult to ...

Bucking conventional, i.e., left-leaning, wisdom for amyloid fibrils, Aβ fibrils extracted from the brains of three people with Alzheimer’s disease all twisted to the right. This is apparent in the ...

The core of the α-synuclein fibril includes a tightly kinked Greek key. Credit: Nat. Struct. Mol. Biol. The hallmarks of many neurodegenerative diseases are brain proteins glomming together into ...

Study may be a step toward shelf-stable versions of the hormone, which is used to control diabetes. Patients with type 1 diabetes have to regularly inject themselves with insulin, a hormone that helps ...

Researchers at MIT have been conducting research that could help people who have type 1 diabetes. People with that medical condition have to inject themselves with insulin to allow their body to ...

Cross section of an alpha-synuclein fibril. Left: 3D reconstruction of the fibril, showing two interacting protein molecules. Right: atomic model of the fibril structure. Disclaimer: AAAS and ...