This review examines the cellular functions of the DNA topoisomerases from a mechanistic point of view. The following points are summarized. Classification of DNA topoisomerases into four subfamilies ...

Shortly after this Review was completed, we were saddened to learn that Dr Tao-shih Hsieh, of Duke University, Durham, North Carolina, USA, and Academia Sinica, Taipei, passed away. Hsieh was a true ...

Cambridge, MA, November 15, 2012 – A group of researchers at the University of California, Berkeley have for the first time described the structure of the active site core of topoisomerase II alpha, ...

A subset (γ2) of late herpes simplex virus 1 genes depends on viral DNA synthesis for its expression. For optimal expression, a small number of these genes, exemplified by US11, also requires two ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, No. 3 (Feb. 5, 2002), pp. 1235-1240 (6 pages) The nonconserved, hydrophilic N-terminal domain of eukaryotic ...

Researchers have identified two natural compounds, patulin and xestoquinol, as new inhibitors of the enzyme topoisomerase 1, a key element in the correct functioning of DNA. The finding, published in ...

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family ...

Topoisomerase II is a key player in both the etiology and treatment of many cancers, including both primary and metastatic diseases. Normally, Topo II creates a transient gate in a DNA duplex by ...

The current pandemic of COVID-19 has taken 1.5 million lives and counting while causing many more people to fall ill. Many studies have shown that adverse outcomes are related to excessive levels of ...

Identifying the primary site using gene expression profiling in patients with carcinoma of an unknown primary (CUP): a feasibility study from the GEFCAPI ...

Medical researchers have for the first time described the structure of the active site core of topoisomerase II alpha, an important target for anti-cancer drugs. The type II topoisomerases are ...