Controlled signaling activity is vital for normal tissue homeostasis and oncogenic signaling activation facilitates tumorigenesis. Here, we combine single-cell transcriptomics with in-depth genetic ...

Colorectal cancer (CRC) is a prevalent and lethal malignancy worldwide, influenced by various factors such as lifestyle choices, environmental exposures, viral infections, and smoking [1,2,3]. Recent ...

Choline kinase α activates the mitogen-activated protein kinase pathway by binding and positively regulating epidermal growth factor receptor, thereby enhancing the proliferative, migrative, and ...

Researchers at the Medical University of Vienna have described a mechanism in metastatic colorectal cancer that has received ...

Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 ...

Racura Oncology Limited (ASX: RAC), a clinical-stage biopharmaceutical company developing new small molecule based approaches to cancer treatment, today announced that the first patient has been dosed ...