Immunotherapy-based combinations have rapidly become the dominant first-line treatment for advanced hepatocellular carcinoma ...
Using high-speed atomic force microscopy (HS-AFM), the Kanazawa University team led by Mikihiro Shibata filmed the dynamic movements of CaMKII at the single-molecule level. The images revealed that a ...
Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows the kinase to repeatedly modify its ...
Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src ...
A recent study has reported that a short-acting mRNA therapy can rejuvenate immune function in older mice by compensating for ...
Researchers at TalTech have concluded that a lack of creatine does not cause heart failure, contrary to previous assumptions.
Recent innovations in targeted protein degradation (TPD) extend beyond small-molecule PROTACs to encompass engineered peptides and recyclable ligand systems. Two complementary strategies─EGFR-directed ...
Background: Hematopoietic progenitor kinase 1 (HPK1) is a member of the mitogen-activated protein kinase kinase kinase kinase (MAP4K) family. It has been reported that HPK1 negatively regulates the ...
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