CD3 is initially expressed in the cytoplasm of pro-thymocytes, the stem cells from which T-cells arise in the thymus. The pro-thymocytes differentiate into common thymocytes, and then into …

CD3 is part of the T-cell receptor (TCR) complex, which is essential for T-cell activation in response to antigens. When T-cells recognize a foreign pathogen, CD3 initiates a cascade of …

Aug 4, 2025 · CD3 (Cluster of Differentiation 3) is a protein complex found on the surface of T cells. It acts as a universal marker for T cells, used to identify and count T cells.

This mini-review explains the structure of CD3, the genes involved in its expression, its function and the signal transduction pathways mediated by CD3 complex.

CD3 is a multimeric protein complex comprising three different subunits: CD3δε, CD3γε, and CD3ζζ dimers. Homologous CD3δε and CD3γε are heterodimers with single extracellular …

Nov 14, 2025 · The CD3 complex acts as the signal transducer, translating external recognition by the TCR into internal cellular action. The complex is composed of multiple protein chains, …

Mar 18, 2022 · CD3 is a cell surface complex composed of 4 distinct subunits; these subunits are chains of integral membrane glycoproteins that associate with T cell antigen receptor (TCR) …

CD3 is not merely an accessory to the T cell receptor; it is essential for the functioning of T cells. Upon antigen recognition, CD3 aids in initiating multiple intracellular signaling cascades.

1 day ago · Learn what CD3 is, how the T cell receptor CD3 complex works, and why human CD3 epsilon is the most important marker in T cell research.

Anti-CD3 antibodies act as potent immunosuppressive agents by modulating the CD3/T-cell receptor (TCR) complex. They have been used in patients to prevent short term allograft …