Peptide Synthesis - an overview | ScienceDirect Topics
Peptide synthesis can be described as a multistep process consisting of the synthesis of partially protected amino acids, activation of the reactive group, along with coupling and final …
Peptide synthesis: Methods, trends, and challenges
Peptide scientists still have a number of synthetic challenges to address including the synthesis of long peptides, bicyclic peptides, pegylated peptides, lipopeptides, glycosylated peptides, cell …
Peptide Synthesis - an overview | ScienceDirect Topics
Peptide synthesis is defined as the formation of a peptide chain through the successive addition of amino acids, which involves a carbon-nitrogen bond-forming reaction essential for producing …
Peptides, solid-phase synthesis and characterization: Tailor-made ...
Jul 1, 2023 · Abstract Background Solid-Phase Peptide Synthesis (SPPS) is a mature technique widely used in research and in production. There are different approaches that fulfill the …
Amide and peptide synthesis via nickel-catalyzed cross …
Nov 20, 2024 · Here, we disclose the first example of amide and peptide synthesis through Ni-catalyzed cross-reductive coupling of electrophile aminating reagents and carboxylic acids. …
Automated solid-phase peptide synthesis to obtain ... - ScienceDirect
Automated solid-phase peptide synthesis (SPPS) offers a suitable technology to produce chemically engineered peptides. This review concentrates on the application of SPPS by …
Artificial intelligence in peptide-based drug design
Feb 1, 2025 · Nonetheless, computational peptide design remains difficult, hindered by the intrinsic flexibility of peptides and the substantial computational resources required. Recent …
Peptide catalysis: Trends and opportunities - ScienceDirect
May 15, 2025 · Challenge: advances in peptide synthesis and screening methodologies suggest that larger and more diverse catalyst libraries are on the horizon. However, the field must …
Development of a novel, automated, robotic system for rapid, high ...
Apr 1, 2023 · The designed TaPSy system can produce peptides with high purity (>70%), even with the green GVL solvent alternative. In this paper we demonstrate the optimization path of a …
Peptide-based drug discovery: Current status and recent advances
Feb 1, 2023 · Peptide therapeutics have gained momentum with the evolution of techniques in peptide chemistry, such as microwave irradiation in solid- and solution-phase synthesis, …